Juniper Publishers-Open Access Journal of Surgery

  Journal of Surgery -  JuniperPublishers System biology and Human microbiota Recent studies have highlighted the oral cavity as a complex biological system organized into several micro and nanoscopic scales, as described by an interdisciplinary field of study using a holistic approach. In this context the recent introduction of the technology of Next Generation Sequencing (NGS) has shed new light on human genomics, but,more especially, has increased the knowledge of the bacterial populations normally resident in the human tissues and called microbiota. NGS, also known as high-throughput sequencing, is a procedure that is able to perform the sequencing in a few hours of both the entire human genome and also the complete profile of the ribosomal gene set or certain genes of interest related to a specific microbiota (metagenomics). Many human tissues, such as the skin, oral cavity, nose, upper air-ways, stomach, lower intestine, and the genito-urinary tract, are colonized by res...

  Journal of Surgery -  JuniperPublishers Nowadays, cervical cancer (CC) is the most common malignancy of the female reproductive system and the fourth most common cancer in general female population [1,2]. The disease is more prevalent among young women and related directly with persistent HPV infection [1,2]. Especially in developing countries CC represents almost 12% of all malignancies in women [1,2]. Additionally, the mortality rate from CC is almost 10-14 times higher in poor and less developed countries (Melanesia, Middle and Eastern Africa), when compared with developed ones (Western Asia, Western Europe, Australia and New Zealand) [1,2]. Based on recently published recommendations and guidelines, the primary management of CC depends mainly on disease stage and could be either surgical or non-surgical (radiotherapy, chemoradiotherapy) [3-5]. Nevertheless, the type and extend of surgical procedure and the type of non-surgical approach should be thoroughly individualized...

Journal of Surgery -  JuniperPublishers Abstract Malignant ascites is an ominous sign that indicates peritoneal metastasis of the primary malignancy. The average survival after development of malignant ascites is only about 5 months. Malignant ascites may be associated with a variety of neoplasms including, ovarian, breast, colo-rectal, gastric, hepatobiliary and pancreatic carcinomas. The ascites per se and need for repeated paracentesis adversely affect the quality of life and also increase the risk of morbidity. Management of malignant ascites is essentially palliative. Conventional first-line approach to a patient with tense ascites includes paracentesis, diuretics or combination of both. Peritoneovenous shunts have also been utilized in selected patients with such situation. However, these approaches have limited efficacy and associated with high morbidity rates. Although effective options for the management of malignant ascites are limited, newer modalities like target...

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